High-Altitude Travel with Medical Problems Travel to high altitude is increasing. The authors
discuss physiological changes at high altitude, pretravel evaluation for common medical …

There is considerable utility in the use of transcranial Doppler ultrasound (TCD) to assess
cerebrovascular function. The brain is unique in its high energy and oxygen demand but …

Key points• The partial pressures of arterial carbon dioxide () and oxygen () has a marked
influence on brain blood flow.• It is unclear if the larger brain arteries are also sensitive to …

This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF).
Evidence for reductions in O2 content (CaO2) rather than arterial O2 tension (PaO2) as the …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Objective: Healthy young adults are presumed to be in their cognitive prime, yet emerging
evidence indicates that regular engagement in physical activity can still benefit their …

We provide an updated review on the current understanding of breathing and sleep at high
altitude in humans. We conclude that:(1) progressive changes in pH initiated by the …

Cerebral hemodynamics and metabolism are frequently impaired in a wide range of
neurological diseases, including traumatic brain injury and stroke, with several …

Quantitative measurements of brain perfusion are influenced by perfusion-modifiers.
Standardization of measurement conditions and correction for important modifiers is …

Abstract Ainslie, Philip N., and Andrew W. Subudhi. Invited Review: Cerebral blood flow at
high altitude. High Alt Med Biol. 15: 133–140, 2014.—This brief review traces the last 50 …