Plant architecture fundamentally differs from that of other multicellular organisms in that
individual cells serve as osmotic bricks, defined by the equilibrium between the internal …

Biomedical scientists use chemistry-driven processes found in nature as an inspiration to
design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue …

Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …

Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

Cellular mechanotransduction, the process of translating mechanical forces into biological
signals, is crucial for a wide range of physiological processes. A role for ion channels in …

Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Much of our understanding of the biological mechanisms that underlie cellular functions,
such as migration, differentiation and force-sensing has been garnered from studying cells …

The topographic features of an implant, which mechanically regulate cell behaviors and
functions, are critical for the clinical success in tissue regeneration. How cells sense and …