Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …

Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

Yes-associated protein (YAP) is a transcriptional co-activator that regulates cell proliferation
and survival by binding to a select set of enhancers for target gene activation. How YAP …

To perceive their three-dimensional environment, cells and tissues must be able to sense
and interpret various physical forces like shear, tensile, and compression stress. These …

TAZ promotes growth, development and tumorigenesis by regulating the expression of
target genes. However, the manner in which TAZ orchestrates the transcriptional responses …

Studies of the regenerative capacity of the liver have converged on the Hippo pathway, a
serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular …

Yes-associated protein (YAP) and TAZ (WW domain containing transcription regulator 1, or
WWTR1) are paralog transcriptional regulators, able to integrate mechanical, metabolic, and …

Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably
leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are …