Advances in fiber optic technology and miniaturized optics and mechanics have propelled
confocal endomicroscopy into the clinical realm. This high resolution, non-invasive imaging …

Relative to other specialties, dermatologists have been slow to adopt advanced technologic
diagnostic aids. After all, most skin disease can be diagnosed by simple visual inspection …

Coherent Raman scattering methods allow for label-free imaging of tissue with chemical
contrast and high spatial and temporal resolution. However, their imaging depth in scattering …

We designed and constructed a single-fiber-optic confocal microscope (SFCM) with a
microelectromechanical system (MEMS) scanner and a miniature objective lens. Axial and …

Laser scanning technology is one of the most integral parts of today's scientific research,
manufacturing, defense and biomedicine. In many applications, high-speed scanning …

Abstract Two-Photon Microscopy has become an invaluable tool for biological and medical
research, providing high sensitivity, molecular specificity, inherent three-dimensional sub …

The purpose of this study was to determine whether in vivo images of oral mucosa obtained
with a fiber optic confocal reflectance microscope could be used to differentiate normal and …

We present a double-clad fiber coupler (DCFC) for use in endoscopy to reduce speckle
contrast, increase signal collection and depth of field. The DCFC is made by fusing and …

We present a novel chromatic confocal microscope capable of volumetric reflectance
imaging of microstructure in non-transparent tissue. Our design takes advantage of the …

Successful treatment of cancer is highly dependent on the stage at which it is diagnosed.
Early diagnosis, when the disease is still localized at its origin, results in very high cure rates …