Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …

Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-
wide screens in human cells,–. Whereas some cell types are amenable to genome …

We recently demonstrated the chemical reprogramming of human somatic cells to
pluripotent stem cells (hCiPSCs), which provides a robust approach for cell fate …

Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …

Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue
dysfunction and disease. At the cellular level, ageing is associated with reduced function …

Rationale: More than 25 million individuals have heart failure worldwide, with≈ 4000
patients currently awaiting heart transplantation in the United States. Donor organ shortage …

Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear
contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about …

The potential of human induced pluripotent stem cells (iPSCs) to self-renew indefinitely and
to differentiate virtually into any cell type in unlimited quantities makes them attractive for in …

Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …