Development of a Scalable Route toward an Alkylated 1, 2, 4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991

R Davenport, A Prud'homme, F Masse… - … Process Research & …, 2023 - ACS Publications
Several synthetic routes toward triazole building block 2-(3-methyl-1 H-1, 2, 4-triazol-1-yl)
acetic acid are described. The main problems of the initial synthetic route via alkylation of 3 …