Aims The aim of this study was to determine the extent to which adherence to individual
vascular medications, assessed by different methods, influences the absolute and relative …

An initiation-promotion protocol was used to test the hypothesis that unleaded gasoline (UG)
vapor acts as a liver tumor promoter in female mice under exposure conditions in which UG …

Importance For patients with limited prognosis, some medication risks may outweigh the
benefits, particularly when benefits take years to accrue; statins are one example. Data are …

Objective The development of these guidelines is mandated by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology …

Background Reducing high blood cholesterol, a risk factor for cardiovascular disease (CVD)
events in people with and without a past history of coronary heart disease (CHD) is an …

Life expectancy has been on the rise for the past few decades, but healthy life expectancy
has not kept pace, leading to a global burden of age-associated disorders. Advancing age is …

GRADE requires guideline developers to make an overall rating of confidence in estimates
of effect (quality of evidence—high, moderate, low, or very low) for each important or critical …

Clinicians, when trying to apply trial results to patient care, need to individualize patient care
and, potentially, manage patients based on results of subgroup analyses. Apparently …

Recommendations about therapy for hypertension are here preceded by some
considerations on the strength of available evidence on the benefits associated with …

Background Statins reduce the incidence of cardiovascular events in patients at high
cardiovascular risk. However, a benefit of statins in such patients who are undergoing …