Pertussis (whooping cough) is a respiratory disease caused primarily by Bordetella
pertussis, a Gram-negative bacteria. Pertussis is a relatively contagious infectious disease in …

Neonates are more susceptible to some pathogens, particularly those that cause infection in
the respiratory tract. This is often attributed to an incompletely developed immune system …

Bordetella pertussis whole-cell vaccines (wP) caused a spectacular drop of global pertussis
incidence, but since the replacement of wP with acellular pertussis vaccines (aP), pertussis …

Current acellular pertussis vaccines fall short of optimal protection against the human
respiratory pathogen Bordetella pertussis resulting in increased incidence of a previously …

Bordetella pertussis colonizes the respiratory mucosa of humans, inducing an immune
response seeded in the respiratory tract. An individual, once convalescent, exhibits long …

The murine Bordetella pertussis challenge model has been utilized in preclinical research
for decades. Currently, inconsistent methodologies are employed by researchers across the …

Introduction Resurgence of pertussis, caused by Bordetella pertussis, necessitates novel
vaccines and vaccination strategies to combat this disease. Alum-adjuvanted acellular …

In the present review, we summarize work from our as well as other groups related to the
characterization of bacterial T cell epitopes, with a specific focus on two important …

Immunization with current acellular pertussis (aP) vaccines protects against severe
pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent …

Acellular multivalent vaccines for pertussis (DTaP and Tdap) prevent symptomatic disease
and infant mortality, but immunity to Bordetella pertussis infection wanes significantly over …