Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

Acute lung injury (ALI) and its severe form, known as acute respiratory distress syndrome
(ARDS), are caused by direct pulmonary insults and indirect systemic inflammatory …

The innate immune system plays a pivotal role in the first line of host defense against
infections and is equipped with patterns recognition receptors (PRRs) that recognize …

Monogenic autoinflammatory diseases are a group of rheumatologic disorders caused by
dysregulation in the innate immune system. The molecular mechanisms of these disorders …

Lung infections caused by the opportunistic pathogen Pseudomonas aeruginosa can
present as a spectrum of clinical entities from a rapidly fatal pneumonia in a neutropenic …

Innate immune system provides the first line of defense against pathogenic organisms. It has
a varied and large collection of molecules known as pattern recognition receptors (PRRs) …

Innate immunity comprises several inflammation-related modulatory pathways which receive
signals from an array of membrane-bound and cytoplasmic pattern recognition receptors …

NOD1 {nucleotide-binding oligomerization domain 1; NLRC [NOD-LRR (leucine-rich repeat)
family with CARD (caspase recruitment domain) 1]} and NOD2 (NLRC2) are among the …

The human host has coevolved with the collective of bacteria species, termed microbiota, in
a complex fashion that affects both innate and adaptive immunity. Differential regulation of …