T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
Why must T cells be cross-reactive?
AK Sewell - Nature Reviews Immunology, 2012 - nature.com
Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …
[HTML][HTML] Deconstructing the peptide-MHC specificity of T cell recognition
In order to survey a universe of major histocompatibility complex (MHC)-presented peptide
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …
Autoimmune T cell responses in the central nervous system
J Goverman - Nature Reviews Immunology, 2009 - nature.com
Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …
How TCRs bind MHCs, peptides, and coreceptors
MG Rudolph, RL Stanfield, IA Wilson - Annu. Rev. Immunol., 2006 - annualreviews.org
Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …
MHC class II proteins and disease: a structural perspective
EY Jones, L Fugger, JL Strominger… - Nature Reviews …, 2006 - nature.com
MHC class II molecules on the surface of antigen-presenting cells display a range of
peptides for recognition by the T-cell receptors of CD4+ T helper cells. Therefore, MHC class …
peptides for recognition by the T-cell receptors of CD4+ T helper cells. Therefore, MHC class …
Chromogranin A is an autoantigen in type 1 diabetes
BD Stadinski, T Delong, N Reisdorph, R Reisdorph… - Nature …, 2010 - nature.com
Autoreactive CD4+ T cells are involved in the pathogenesis of many autoimmune diseases,
but the antigens that stimulate their responses have been difficult to identify and in most …
but the antigens that stimulate their responses have been difficult to identify and in most …
Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells
The nature of the antigens recognized by γδ T cells and their potential recognition of major
histocompatibility complex (MHC)-like molecules has remained unclear. Members of the …
histocompatibility complex (MHC)-like molecules has remained unclear. Members of the …
Structural determinants of T-cell receptor bias in immunity
Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or
hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors …
hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors …
Specificity of T-cell alloreactivity
NJ Felix, PM Allen - Nature Reviews Immunology, 2007 - nature.com
T-cell alloreactivity is a well-established phenomenon, but its molecular basis has remained
enigmatic. Although there are differences between T-cell recognition of conventional and …
enigmatic. Although there are differences between T-cell recognition of conventional and …