The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …

In order to survey a universe of major histocompatibility complex (MHC)-presented peptide
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …

Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

MHC class II molecules on the surface of antigen-presenting cells display a range of
peptides for recognition by the T-cell receptors of CD4+ T helper cells. Therefore, MHC class …

Autoreactive CD4+ T cells are involved in the pathogenesis of many autoimmune diseases,
but the antigens that stimulate their responses have been difficult to identify and in most …

The nature of the antigens recognized by γδ T cells and their potential recognition of major
histocompatibility complex (MHC)-like molecules has remained unclear. Members of the …

Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or
hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors …

T-cell alloreactivity is a well-established phenomenon, but its molecular basis has remained
enigmatic. Although there are differences between T-cell recognition of conventional and …