The mechanical properties of soft tissues play a key role in studying human injuries and their
mitigation strategies. While such properties are indispensable for computational modelling …

Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

Mechanics are increasingly recognized to play an important role in modulating brain form
and function. Computational simulations are a powerful tool to predict the mechanical …

Tumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins
are mechanotransducers that regulate cell fate, we asked whether tissue stiffness could …

All cells are influenced by mechanical forces. In the brain, force-generating and load-
bearing proteins twist, turn, ratchet, flex, compress, expand and bend to mediate neuronal …

Owing to the insufficient guidance of new bone formation in orthopedic and
craniomaxillofacial surgery, construction of a guided bone regeneration membrane to …

Cortical neurons and astrocytes respond strongly to changes in matrix rigidity when cultured
on flexible substrates. In this study, existing polyacrylamide gel polymerization methods …

Abstract Changes in tissue composition and cellular architecture have been associated with
neurological disease, and these in turn can affect biomechanical properties. Natural …

Traumatic brain injury (TBI) is a significant public health problem, on pace to become the
third leading cause of death worldwide by 2020. Moreover, emerging evidence linking …

Matrix and tissue rigidity guides many cellular processes, including the differentiation of
stem cells and the migration of cells in health and disease. Cells actively and transiently test …