Stress-related biomolecular condensates in plants

J Solis-Miranda, M Chodasiewicz, A Skirycz… - The Plant …, 2023 - academic.oup.com
Biomolecular condensates are membraneless organelle-like structures that can concentrate
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …

Kinase regulation by liquid–liquid phase separation

TP López-Palacios, JL Andersen - Trends in Cell Biology, 2023 - cell.com
Liquid–liquid phase separation (LLPS) is emerging as a mechanism of spatiotemporal
regulation that could answer long-standing questions about how order is achieved in …

CD-CODE: crowdsourcing condensate database and encyclopedia

N Rostam, S Ghosh, CFW Chow, A Hadarovich… - Nature …, 2023 - nature.com
The discovery of biomolecular condensates transformed our understanding of intracellular
compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about …

RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding

E Zacco, L Broglia, M Kurihara, M Monti… - Chemical …, 2024 - ACS Publications
This comprehensive Review delves into the chemical principles governing RNA-mediated
crowding events, commonly referred to as granules or biological condensates. We explore …

Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression

Y Liu, Q Li, L Song, C Gong, S Tang… - Cancer …, 2024 - aacrjournals.org
Gain-of-function mutations in the histone acetylation “reader” eleven-nineteen-leukemia
(ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known to drive …

Biomolecular condensates in kidney physiology and disease

G Gao, ES Sumrall, S Pitchiaya, M Bitzer… - Nature Reviews …, 2023 - nature.com
The regulation and preservation of distinct intracellular and extracellular solute
microenvironments is crucial for the maintenance of cellular homeostasis. In mammals, the …

Liquid–liquid phase separation in diseases

X Zhang, L Yuan, W Zhang, Y Zhang, Q Wu, C Li… - MedComm, 2024 - Wiley Online Library
Liquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can
sequester molecules to implement physiological and pathological functions. LLPS …

RNA‐Selective Small‐Molecule Ligands: Recent Advances in Live‐Cell Imaging and Drug Discovery

KH Chan, Y Wang, BX Zheng, W Long, X Feng… - …, 2023 - Wiley Online Library
RNA structures, including those formed from coding and noncoding RNAs, alternative to
protein‐based drug targets, could be a promising target of small molecules for drug …

Splicing regulation through biomolecular condensates and membraneless organelles

J Giudice, H Jiang - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Biomolecular condensates, sometimes also known as membraneless organelles (MLOs),
can form through weak multivalent intermolecular interactions of proteins and nucleic acids …

Global discovery of covalent modulators of ribonucleoprotein granules

AM Ciancone, KW Seo, M Chen, AL Borne… - Journal of the …, 2023 - ACS Publications
Stress granules (SGs) and processing-bodies (PBs, P-bodies) are ubiquitous and widely
studied ribonucleoprotein (RNP) granules involved in cellular stress response, viral …