Bright side of lignin depolymerization: toward new platform chemicals

Z Sun, B Fridrich, A De Santi, S Elangovan… - Chemical …, 2018 - ACS Publications
Lignin, a major component of lignocellulose, is the largest source of aromatic building blocks
on the planet and harbors great potential to serve as starting material for the production of …

Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases

M Shibuya - The Journal of Biochemistry, 2013 - academic.oup.com
Vascular endothelial growth factors (VEGFs) belong to the platelet-derived growth factor
supergene family, and they play central roles in the regulation of angiogenesis and …

[HTML][HTML] Combinatorial epigenetics impact of polyphenols and phytochemicals in cancer prevention and therapy

I Arora, M Sharma, TO Tollefsbol - International journal of molecular …, 2019 - mdpi.com
Polyphenols are potent micronutrients that can be found in large quantities in various food
sources and spices. These compounds, also known as phenolics due to their phenolic …

Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances

F Zálešák, DJYD Bon, J Pospíšil - Pharmacological Research, 2019 - Elsevier
Lignans and neolignans are plant secondary metabolites derived from the oxidative
coupling of phenylpropanoids. Biological activity of these phenolic compounds ranges from …

[HTML][HTML] Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L

Q Gao, M Yang, Z Zuo - Acta Pharmacologica Sinica, 2018 - nature.com
Arctigenin (AR) and its glycoside, arctiin, are two major active ingredients of Arctium lappa L
(A lappa), a popular medicinal herb and health supplement frequently used in Asia. In the …

A review of the pharmacological effects of Arctium lappa (burdock)

YS Chan, LN Cheng, JH Wu, E Chan, YW Kwan… - …, 2011 - Springer
Arctium lappa, commonly known as burdock, is being promoted/recommended as a healthy
and nutritive food in Chinese societies. Burdock has been used therapeutically in Europe …

[HTML][HTML] 3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

C Wenzel, B Riefke, S Gründemann, A Krebs… - Experimental cell …, 2014 - Elsevier
Cancer cells in poorly vascularized tumor regions need to adapt to an unfavorable metabolic
microenvironment. As distance from supplying blood vessels increases, oxygen and nutrient …

Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves

R Ferracane, G Graziani, M Gallo, V Fogliano… - … of pharmaceutical and …, 2010 - Elsevier
In this work the bioactive metabolic profile, the antioxidant activity and total phenolic content
of burdock (Arctium lappa) seeds, leaves and roots were obtained. TEAC values and total …

In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway

F Zhao, L Wang, K Liu - Journal of ethnopharmacology, 2009 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Arctigenin, a bioactive constituent from dried
seeds of Arctium lappa L.(Compositae) which has been widely used as a Traditional …

HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression

B Philip, K Ito, R Moreno-Sánchez, SJ Ralph - Carcinogenesis, 2013 - academic.oup.com
Hypoxic microenvironments frequently exist in many solid tumours with oxygen levels
fluctuating temporally and spatially from normoxia to hypoxia. The response to hypoxia in …