The Discovery of Extracellular Vesicles and Their Emergence as a Next-Generation Therapy

A Rai, B Claridge, J Lozano, DW Greening - Circulation Research, 2024 - Am Heart Assoc
From their humble discovery as cellular debris to cementing their natural capacity to transfer
functional molecules between cells, the long-winded journey of extracellular vesicles (EVs) …

Effects of Chronic Inflammatory Activation of Murine and Human Arterial Endothelial Cells at Normal Lipoprotein and Cholesterol Levels In Vivo and In Vitro

M Mussbacher, J Basílio, B Belakova, A Pirabe… - Cells, 2024 - mdpi.com
The activation of endothelial cells is crucial for immune defense mechanisms but also plays
a role in the development of atherosclerosis. We have previously shown that inflammatory …

Multi-omic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks

S Raju, ME Turner, C Cao, M Abdul-Samad, N Punwasi… - bioRxiv, 2024 - biorxiv.org
Background Carotid atherosclerosis is a multifaceted disease orchestrated by a myriad of
cell-cell communication that drives progression along a clinical continuum (asymptomatic to …