Amyloid-beta (Aβ) plays an important role in the pathogenesis of Alzheimer's disease.
Aberrant Aβ accumulation induces neuroinflammation, cerebrovascular alterations, and …

Proton magnetic resonance spectroscopy (1H-MRS) is sensitive to early neurodegenerative
processes associated with Alzheimer's disease (AD). Although 1H-MRS metabolite ratios of …

This review presents an overview of some of the pre-clinical and clinical issues that have
contributed to the failures of potential novel neuropsychiatric drugs, which have prompted a …

Objective To investigate the association between longitudinal changes in proton magnetic
resonance spectroscopy (MRS) metabolites and amyloid pathology in individuals without …

There is increasing evidence linking neuroinflammation to many neurological disorders
including Alzheimer's disease (AD); however, its exact contribution to disease manifestation …

Objective Increasing evidence suggests that reactive astrocytes are associated with
Alzheimer's disease (AD). However, its underlying pathogenesis remains unknown. Given …

This paper reports on the development of an amperometric method for the determination of
myo-inositol. The method involves coating of a glassy carbon electrode (GCE) with a …

Microglia activation has emerged as a potential key factor in the pathogenesis of Alzheimer's
disease. Metabolite levels assessed by magnetic resonance spectroscopy (MRS) are used …

Objective: To assess whether noninvasive proton magnetic resonance spectroscopy (1H-
MRS) tissue metabolite measurements at baseline can predict an increase in the rate of β …

Myo-inositol exerts many cellular functions, which include osmo-protection, membrane
functioning, and secondary messaging. Its Na+/myo-inositol co-transporter SLC5A3 is …