Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …

Extracellular adenosine is a potent immunosuppressor that accumulates during tumor
growth. We performed proof-of-concept studies investigating the therapeutic potential and …

In ischemic stroke, the primary neuronal injury caused by the disruption of energy supply is
further exacerbated by secondary sterile inflammation. The inflammatory cascade is largely …

Purine nucleotides and nucleosides are at the center of biologic reactions. In particular,
adenosine triphosphate (ATP) is the fundamental energy currency of cellular activity and …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

Despite increasing availability and more successful interventional approaches to restore
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …

Nucleotides and nucleosides—such as adenosine triphosphate (ATP) and adenosine—are
famous for their intracellular roles as building blocks for the genetic code or cellular energy …

Sepsis and septic acute lung injury are among the leading causes for morbidity and mortality
of critical illness. Extracellular adenosine is a signaling molecule implicated in the cellular …

Mammals have evolved to adapt to differences in oxygen availability. Although systemic
oxygen homeostasis relies on respiratory and circulatory responses, cellular adaptation to …