In patients with cystic fibrosis (CF), genetic variants within and outside the CFTR locus
contribute to the variability of the disease severity. CFTR transcription is tightly regulated by …

Remarkable progress in CFTR research has led to the therapeutic development of
modulators that rescue the basic defect in cystic fibrosis. There is continuous interest in …

Rationale: Animal models have been highly informative for understanding the
characteristics, onset, and progression of cystic fibrosis (CF) lung disease. In particular, the …

The CFTR gene displays a tightly regulated tissue-specific and temporal expression.
Mutations in this gene cause cystic fibrosis (CF). In this study we wanted to identify trans …

We aimed to refine the value of CDX 2 as an independent prognostic and predictive
biomarker in colorectal cancer (CRC) according to disease stage and chemotherapy …

Higher order chromatin structure establishes domains that organize the genome and
coordinate gene expression. However, the molecular mechanisms controlling transcription …

The differentiated functions of the human airway epithelium are coordinated by a complex
network of transcription factors. These include the pioneer factors Forkhead box A1 and A2 …

Cystic fibrosis transmembrane conductance regulator gene (CFTR) expression in human
airway epithelial cells involves the recruitment of distal cis-regulatory elements, which are …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause
the inherited disorder cystic fibrosis (CF). Lung disease is the major cause of CF morbidity …

We identified and characterized multiple cell‐type selective enhancers of the CFTR gene
promoter in previous work and demonstrated active looping of these elements to the …