The concept that dietary changes could improve the response to cancer therapy is extremely
attractive to many patients, who are highly motivated to take control of at least some aspect …

Warburg's hypothesis that cancer cells take up a lot of glucose in the presence of ambient
oxygen but convert pyruvate into lactate due to impaired mitochondrial function led to the …

Many tumour cells show dependence on exogenous serine and dietary serine and glycine
starvation can inhibit the growth of these cancers and extend survival in mice. However …

Despite recent advancements in the treatment of hematologic malignancies and the
emergence of newer and more sophisticated therapeutic approaches such as …

Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to
feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic …

The main hematopoietic stem cell (HSC) functions, self-renewal and differentiation, are
finely regulated by both intrinsic mechanisms such as transcriptional and epigenetic …

Serine, a non-essential amino acid, can be imported from the extracellular environment by
transporters and de novo synthesized from glycolytic 3-phosphoglycerate (3-PG) in the …

The serine synthesis pathway (SSP) is active in multiple cancers. Previous study has shown
that bortezomib (BTZ) resistance is associated with an increase in the SSP in multiple …

Cancer-associated mutations in the spliceosome gene SF3B1 create a neomorphic protein
that produces aberrant mRNA splicing in hundreds of genes, but the ensuing biologic and …

Metabolic rewiring and cellular reprogramming are trademarks of neoplastic initiation and
progression in acute myeloid leukemia (AML). Metabolic alteration in leukemic cells is often …