Dietary approaches to cancer therapy
M Tajan, KH Vousden - Cancer cell, 2020 - cell.com
The concept that dietary changes could improve the response to cancer therapy is extremely
attractive to many patients, who are highly motivated to take control of at least some aspect …
attractive to many patients, who are highly motivated to take control of at least some aspect …
Cancer cell metabolism and mitochondria: Nutrient plasticity for TCA cycle fueling
Warburg's hypothesis that cancer cells take up a lot of glucose in the presence of ambient
oxygen but convert pyruvate into lactate due to impaired mitochondrial function led to the …
oxygen but convert pyruvate into lactate due to impaired mitochondrial function led to the …
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
M Tajan, M Hennequart, EC Cheung, F Zani… - Nature …, 2021 - nature.com
Many tumour cells show dependence on exogenous serine and dietary serine and glycine
starvation can inhibit the growth of these cancers and extend survival in mice. However …
starvation can inhibit the growth of these cancers and extend survival in mice. However …
The importance of cellular metabolic pathways in pathogenesis and selective treatments of hematological malignancies
Despite recent advancements in the treatment of hematologic malignancies and the
emergence of newer and more sophisticated therapeutic approaches such as …
emergence of newer and more sophisticated therapeutic approaches such as …
Metabolic dependencies and vulnerabilities in leukemia
M Rashkovan, A Ferrando - Genes & development, 2019 - genesdev.cshlp.org
Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to
feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic …
feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic …
[HTML][HTML] Oxidative stress and hypoxia in normal and leukemic stem cells
U Testa, C Labbaye, G Castelli, E Pelosi - Experimental hematology, 2016 - Elsevier
The main hematopoietic stem cell (HSC) functions, self-renewal and differentiation, are
finely regulated by both intrinsic mechanisms such as transcriptional and epigenetic …
finely regulated by both intrinsic mechanisms such as transcriptional and epigenetic …
[HTML][HTML] The role of D-3-phosphoglycerate dehydrogenase in cancer
X Zhao, J Fu, J Du, W Xu - International journal of biological …, 2020 - ncbi.nlm.nih.gov
Serine, a non-essential amino acid, can be imported from the extracellular environment by
transporters and de novo synthesized from glycolytic 3-phosphoglycerate (3-PG) in the …
transporters and de novo synthesized from glycolytic 3-phosphoglycerate (3-PG) in the …
Phosphoglycerate dehydrogenase promotes proliferation and bortezomib resistance through increasing reduced glutathione synthesis in multiple myeloma
X Wu, J Xia, J Zhang, Y Zhu, Y Wu… - British journal of …, 2020 - Wiley Online Library
The serine synthesis pathway (SSP) is active in multiple cancers. Previous study has shown
that bortezomib (BTZ) resistance is associated with an increase in the SSP in multiple …
that bortezomib (BTZ) resistance is associated with an increase in the SSP in multiple …
Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation
WB Dalton, E Helmenstine, N Walsh… - The Journal of …, 2019 - Am Soc Clin Investig
Cancer-associated mutations in the spliceosome gene SF3B1 create a neomorphic protein
that produces aberrant mRNA splicing in hundreds of genes, but the ensuing biologic and …
that produces aberrant mRNA splicing in hundreds of genes, but the ensuing biologic and …
Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targets
SK Mishra, SE Millman, L Zhang - Blood, 2023 - ashpublications.org
Metabolic rewiring and cellular reprogramming are trademarks of neoplastic initiation and
progression in acute myeloid leukemia (AML). Metabolic alteration in leukemic cells is often …
progression in acute myeloid leukemia (AML). Metabolic alteration in leukemic cells is often …