Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Antibiotic resistance is a significant emerging health threat. Exacerbating this problem is the
overprescription of antibiotics as well as a lack of development of new antibacterial agents …

A comprehensive guide to privileged structures and their application in the discovery of new
drugs The use of privileged structures is a viable strategy in the discovery of new medicines …

The adamantane moiety has attracted significant attention since its discovery in 1933 due to
its remarkable structural, chemical, and medicinal properties. This molecule has a notable …

Botulinum toxins are neurotoxins produced by Clostridium botulinum. This toxin can be
lethal for humans as a cause of botulism; however, in small doses, the same toxin is used to …

Substituted hydroxamic acid is one of the most extensively studied pharmacophores
because of their ability to chelate biologically important metal ions to modulate various …

ABSTRACT Introduction: Botulinum neurotoxins (BoNTs) are the most potent toxins known.
BoNTs are responsible for botulism, a deadly neuroparalytic syndrome caused by the …

Conspectus Botulinum neurotoxin serotype A (BoNT/A), marketed commercially as Botox, is
the most toxic substance known to man with an estimated intravenous lethal dose (LD50) of …

Abstract Botulinum neurotoxin A (BoNT/A) is the most potent toxin known. Unfortunately, it is
also a potential bioweapon in terrorism, which is without an approved therapeutic treatment …

Botulinum neurotoxins have remarkable persistence (∼ weeks to months in cells), outlasting
the small-molecule inhibitors designed to target them. To address this disconnect, inhibitors …