The emerging roles of circRNAs in cancer and oncology

LS Kristensen, T Jakobsen, H Hager… - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

Proteogenomic data and resources for pan-cancer analysis

Y Li, Y Dou, FDV Leprevost, Y Geffen, AP Calinawan… - Cancer cell, 2023 - cell.com
Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …

[HTML][HTML] Proteogenomic characterization of pancreatic ductal adenocarcinoma

L Cao, C Huang, DC Zhou, Y Hu, TM Lih, SR Savage… - Cell, 2021 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …

[HTML][HTML] Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma

L Dong, D Lu, R Chen, Y Lin, H Zhu, Z Zhang, S Cai… - Cancer cell, 2022 - cell.com
We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA)
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …

Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways

Y Zhang, F Chen, DS Chandrashekar… - Nature …, 2022 - nature.com
Mass-spectrometry-based proteomic data on human tumors—combined with corresponding
multi-omics data—present opportunities for systematic and pan-cancer proteogenomic …

Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma

MA Gillette, S Satpathy, S Cao, SM Dhanasekaran… - Cell, 2020 - cell.com
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …

Cancer proteogenomics: current impact and future prospects

DR Mani, K Krug, B Zhang, S Satpathy… - Nature Reviews …, 2022 - nature.com
Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …

Application of proteomics in cancer: recent trends and approaches for biomarkers discovery

YW Kwon, HS Jo, S Bae, Y Seo, P Song, M Song… - Frontiers in …, 2021 - frontiersin.org
Proteomics has become an important field in molecular sciences, as it provides valuable
information on the identity, expression levels, and modification of proteins. For example …

Integrated proteogenomic characterization across major histological types of pediatric brain cancer

F Petralia, N Tignor, B Reva, M Koptyra, S Chowdhury… - Cell, 2020 - cell.com
We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Data‐independent acquisition mass spectrometry‐based proteomics and software tools: a glimpse in 2020

F Zhang, W Ge, G Ruan, X Cai, T Guo - Proteomics, 2020 - Wiley Online Library
This review provides a brief overview of the development of data‐independent acquisition
(DIA) mass spectrometry‐based proteomics and selected DIA data analysis tools. Various …