[HTML][HTML] Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

[HTML][HTML] Repurposing immunomodulatory drugs to combat tuberculosis

S Fatima, A Bhaskar, VP Dwivedi - Frontiers in Immunology, 2021 - frontiersin.org
Tuberculosis (TB) is an infectious disease caused by an obligate intracellular pathogen,
Mycobacterium tuberculosis (M. tb) and is responsible for the maximum number of deaths …

[HTML][HTML] Postnatal infection is associated with widespread abnormalities of brain development in premature newborns

V Chau, R Brant, KJ Poskitt, EWY Tam, A Synnes… - Pediatric …, 2012 - nature.com
Results: In 34/117 newborns studied, clinical signs were accompanied by positive cultures
whereas 17 had clinical signs of sepsis alone. White matter injury (WMI) was identified in 34 …

Inflammation-initiating illnesses, inflammation-related proteins, and cognitive impairment in extremely preterm infants

TM O'Shea, B Shah, EN Allred, RN Fichorova… - Brain, behavior, and …, 2013 - Elsevier
Neonatal inflammation is associated with perinatal brain damage. We evaluated to what
extent elevated blood levels of inflammation-related proteins supplement information about …

A review of immunomodulatory effects of fluoroquinolones

S Assar, R Nosratabadi… - Immunological …, 2021 - Taylor & Francis
Past researches indicate that some types of antibiotics, apart from their antimicrobial effects,
have some other important effects which indirectly are exerted by modulating and regulating …

[HTML][HTML] Narciclasine improves outcome in sepsis among neonatal rats via inhibition of calprotectin and alleviating inflammatory responses

MK Kingsley, BV Bhat, BA Badhe, BB Dhas… - Scientific Reports, 2020 - nature.com
Sepsis is associated with exacerbated inflammatory response which subsequently results in
multiple organ dysfunction. Sepsis accounts for high mortality and morbidity among …

Population pharmacokinetics of ciprofloxacin in neonates and young infants less than three months of age

W Zhao, H Hill, C Le Guellec, T Neal… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Ciprofloxacin is used in neonates with suspected or documented Gram-negative serious
infections. Currently, its use is off-label partly because of lack of pharmacokinetic studies …

Effects of neonatal systemic inflammation on blood‐brain barrier permeability and behaviour in juvenile and adult rats

HB Stolp, PA Johansson, MD Habgood… - Cardiovascular …, 2011 - Wiley Online Library
Several neurological disorders have been linked to inflammatory insults suffered during
development. We investigated the effects of neonatal systemic inflammation, induced by …

Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities

D Brites, A Fernandes - Seminars in Fetal and Neonatal Medicine, 2015 - Elsevier
Bilirubin-induced neurologic dysfunction (BIND) and classical kernicterus are clinical
manifestations of moderate to severe hyperbilirubinemia whenever bilirubin levels exceed …

Infection‐induced vulnerability of perinatal brain injury

C Mallard, X Wang - Neurology research international, 2012 - Wiley Online Library
A growing body of evidence demonstrates that susceptibility and progression of both acute
and chronic central nervous system disease in the newborn is closely associated with an …