HIV-associated cardiovascular disease pathogenesis: an emerging understanding through imaging and immunology

JA Hudson, RA Ferrand, SN Gitau… - Circulation …, 2024 - Am Heart Assoc
Cardiac abnormalities were identified early in the epidemic of AIDS, predating the isolation
and characterization of the etiologic agent, HIV. Several decades later, the causation and …

[HTML][HTML] Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice

J Liu, J Shi, R Hernandez, X Li, P Konchadi… - Environment …, 2023 - Elsevier
Exposure to ubiquitous plastic-associated endocrine disrupting chemicals (EDCs) is
associated with the increased risk of many chronic diseases. For example, phthalate …

[HTML][HTML] An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages

S Satta, Z Meng, R Hernandez, S Cavallero, T Zhou… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Macrophages are the frontline immune cells in response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting …

Pregnane X receptor mediates atherosclerosis induced by dicyclohexyl phthalate in LDL receptor-deficient mice

J Liu, R Hernandez, X Li, Z Meng, H Chen, C Zhou - Cells, 2022 - mdpi.com
Plastic-associated endocrine disrupting chemicals (EDCs) have been implicated in the
etiology of cardiovascular disease (CVD) in humans, but the underlying mechanisms remain …

NF-κB/ABCA1 pathway aggravates ox-LDL-induced cell pyroptosis by activation of NLRP3 inflammasomes in THP-1-derived macrophages

J Li, J Liu, Y Yu, Y Liu, X Guan - Molecular Biology Reports, 2022 - Springer
Objective NF-κB (nuclear transcription factor-kappa B) plays a well-known function in the
regulation of immune responses and inflammation, but growing evidences support a major …

[HTML][HTML] Fibroblast-specific IKK-β deficiency ameliorates angiotensin II–induced adverse cardiac remodeling in mice

W Lu, Z Meng, R Hernandez, C Zhou - JCI insight, 2021 - ncbi.nlm.nih.gov
Cardiac inflammation and fibrosis contribute significantly to hypertension-related adverse
cardiac remodeling. IκB kinase β (IKK-β), a central coordinator of inflammation through …

Paternal hypercholesterolemia elicits sex-specific exacerbation of atherosclerosis in offspring

R Hernandez, X Li, J Shi, TR Dave, T Zhou… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Emerging studies suggest that various parental exposures affect offspring cardiovascular
health, yet the specific mechanisms, particularly the influence of paternal cardiovascular …

HIV-1 Tat Upregulates the Receptor for Advanced Glycation End Products and Superoxide Dismutase-2 in the Heart of Transgenic Mice

AN Qrareya, NS Wise, ER Hodges, F Mahdi… - Viruses, 2022 - mdpi.com
Cardiovascular disorder (CVD) is a common comorbidity in people living with HIV (PLWH).
Although the underlying mechanisms are unknown, virotoxic HIV proteins, such as the trans …

[PDF][PDF] 炎症在HIV 携带者中高血压的研究进展

毛亚超, 付海艳, 杜映荣, 陆霓虹 - 实用预防医学 - syyfyx.com
由于抗逆转录病毒药物的规范使用, 艾滋病患者的生存期明显延长, 与年龄相关的心血管疾病
日渐增多. 高血压作为最常见的心血管疾病, 在HIV 携带者(people living with HIV, PLWH) …

Novel Insights Into the Mechanisms of Atherosclerosis

R Hernandez - 2024 - search.proquest.com
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of
lipids, immune cells, necrotic cells, and other fibrous material in the subintimal space of …