Compared with the extensive knowledge on cell division in model eukaryotes and bacteria,
little is known about how archaea divide. Interestingly, both endosomal sorting complex …

There has long been a fascination in the DNA repair pathways of archaea, for two main
reasons. Firstly, many archaea inhabit extreme environments where the rate of physical …

Archaea often thrive in environmental extremes, enduring levels of heat, pressure, salinity,
pH, and radiation that prove intolerable to most life. Many environmental extremes raise the …

The tree of life shows the relationship between all organisms based on their common
ancestry. Until 1977, it comprised two major branches: prokaryotes and eukaryotes. Work by …

The model haloarchaeon Haloferax volcanii is polyploid with about 20 copies of its major
chromosome. Recently it has been described that highly efficient intermolecular gene …

Highlights•Hef may function in stalled fork repair by association of its IDR with multiple
partners.•EndoQ cleaves the phosphodiester bond 5′ from dI, dU, dX, and the AP site in …

The success of biotechnological processes is based on the availability of efficient and highly
specific biocatalysts, which can satisfy industrial demands. Extreme and remote …

Hef is an archaeal protein that probably functions mainly in stalled replication fork repair.
The presence of an unstructured region was predicted between the two distinct domains of …

Stable isotope labelling of amino acids in cell culture (SILAC) is a quantitative proteomic
method that can illuminate new pathways used by cells to adapt to different lifestyles and …

Using the haloarchaeon Haloferax volcanii as a model, we developed nascent DNA labeling
and the functional GFP-labeled single-stranded binding protein RPA2 as novel tools to gain …