Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the
adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium …

The standard model of adrenocortical zonation holds that the three main zones,
glomerulosa, fasciculata, and reticularis each have a distinct function, producing …

Evolution has resulted in profound differences between males and females that extend to
non-reproductive organs and are reflected in the susceptibility and progression of diseases …

Activating mutations in the canonical Wnt/β-catenin pathway are key drivers of hyperplasia,
the gateway for tumor development. In a wide range of tissues, this occurs primarily through …

The atrophy and hypofunction of the adrenal cortex following long-term pharmacologic
glucocorticoid therapy is a major health problem necessitating chronic glucocorticoid …

Stem cells are endowed with the potential for self-renewal and multipotency. Pluripotent
embryonic stem cells have an early role in the formation of the three germ layers (ectoderm …

Context: Primary aldosteronism is one of the leading causes of secondary hypertension,
causing significant morbidity and mortality. A number of genetic defects have recently been …

The adrenal glands are paired endocrine organs that produce steroid hormones and
catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal …

The adult adrenal cortex is organized into concentric zones, each specialized to produce
distinct steroid hormones. Cellular composition of the cortex is highly dynamic and subject to …

Many adrenocortical diseases are more prevalent in women than in men, but the reasons
underlying this sex bias are still unknown. Recent studies involving gonadectomy and sex …