GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

Imbalances between excitation and inhibition in synaptic transmission and neural circuits
have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are …

Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that include
a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and …

Autism spectrum disorders (ASD) and epilepsy are common neurological diseases of
childhood, with an estimated incidence of approximately 0.5–1% of the worldwide …

γ-Aminobutyric acid (GABA), the main inhibitory neurotransmitter in the adult brain, early in
postnatal life exerts a depolarizing and excitatory action. This depends on accumulation of …

The cerebellum has been long known for its importance in motor learning and coordination.
Recently, anatomical, clinical, and neuroimaging studies strongly suggest that the …

Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder
associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) …

Key points Here we show that glial gamma aminobutyric acid (GABA) is produced by
monoamine oxidase B (MAOB), utilizing a polyamine, putrescine. The concentration of …

Angelman Syndrome (AS) is characterized by severe developmental delays including
marked speech impairment, movement abnormalities (ataxia, tremor), and unique behaviors …

UBE3A is a gene implicated in neurodevelopmental disorders. The protein product of
UBE3A is the E3 ligase E6-associated protein (E6AP), and its expression in the brain is …