The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

[HTML][HTML] Microfluidic-based technologies for CTC isolation: a review of 10 years of intense efforts towards liquid biopsy

L Descamps, D Le Roy, AL Deman - International Journal of Molecular …, 2022 - mdpi.com
The selection of circulating tumor cells (CTCs) directly from blood as a real-time liquid
biopsy has received increasing attention over the past ten years, and further analysis of …

[HTML][HTML] A high-dimensional microfluidic approach for selection of aptamers with programmable binding affinities

D Chang, Z Wang, CD Flynn, A Mahmud, M Labib… - Nature …, 2023 - nature.com
Aptamers are being applied as affinity reagents in analytical applications owing to their high
stability, compact size and amenability to chemical modification. Generating aptamers with …

Precise subcellular organelle targeting for boosting endogenous‐stimuli‐mediated tumor therapy

W Zhen, S An, S Wang, W Hu, Y Li, X Jiang… - Advanced …, 2021 - Wiley Online Library
Though numerous external‐stimuli‐triggered tumor therapies, including phototherapy,
radiotherapy, and sonodynamic therapy have made great progress in cancer therapy, the …

Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting

Z Wang, S Ahmed, M Labib, H Wang, L Wu… - Nature Biomedical …, 2023 - nature.com
The clinical use of tumour-infiltrating lymphocytes for the treatment of solid tumours is
hindered by the need to obtain large and fresh tumour fractions, which is often not feasible in …

Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting

Z Wang, S Ahmed, M Labib, H Wang, X Hu… - Nature Biomedical …, 2022 - nature.com
Adoptive cell therapies require the recovery and expansion of highly potent tumour-
infiltrating lymphocytes (TILs). However, TILs in tumours are rare and difficult to isolate …

Nanoparticle amplification labeling for high-performance magnetic cell sorting

Z Wang, H Wang, S Lin, S Ahmed, S Angers… - Nano …, 2022 - ACS Publications
Magnetic cell sorting is an enabling tool for the isolation of specific cellular subpopulations
for downstream applications and requires the cells to be labeled by a sufficient number of …

Bioorthogonal microbubbles with antifouling nanofilm for instant and suspended enrichment of circulating tumor cells

Y Xiang, H Zhang, H Lu, B Wei, C Su, X Qin, M Fang… - ACS …, 2023 - ACS Publications
Integrating clinical rare cell enrichment, culture, and single-cell phenotypic profiling is
currently hampered by the lack of competent technologies, which typically suffer from weak …

[HTML][HTML] Integrated microfluidic single-cell immunoblotting chip enables high-throughput isolation, enrichment and direct protein analysis of circulating tumor cells

A Abdulla, T Zhang, S Li, W Guo, AR Warden… - Microsystems & …, 2022 - nature.com
Effective capture and analysis of a single circulating tumor cell (CTC) is instrumental for
early diagnosis and personalized therapy of tumors. However, due to their extremely low …

Poly (ethylene oxide) concentration gradient-based microfluidic isolation of circulating tumor cells

Y Cheng, S Zhang, L Qin, J Zhao, H Song… - Analytical …, 2023 - ACS Publications
Circulating tumor cells (CTCs) have emerged as promising circulating biomarkers for non-
invasive cancer diagnosis and management. Isolation and detection of CTCs in clinical …