The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
[HTML][HTML] Microfluidic-based technologies for CTC isolation: a review of 10 years of intense efforts towards liquid biopsy
L Descamps, D Le Roy, AL Deman - International Journal of Molecular …, 2022 - mdpi.com
The selection of circulating tumor cells (CTCs) directly from blood as a real-time liquid
biopsy has received increasing attention over the past ten years, and further analysis of …
biopsy has received increasing attention over the past ten years, and further analysis of …
[HTML][HTML] A high-dimensional microfluidic approach for selection of aptamers with programmable binding affinities
Aptamers are being applied as affinity reagents in analytical applications owing to their high
stability, compact size and amenability to chemical modification. Generating aptamers with …
stability, compact size and amenability to chemical modification. Generating aptamers with …
Precise subcellular organelle targeting for boosting endogenous‐stimuli‐mediated tumor therapy
W Zhen, S An, S Wang, W Hu, Y Li, X Jiang… - Advanced …, 2021 - Wiley Online Library
Though numerous external‐stimuli‐triggered tumor therapies, including phototherapy,
radiotherapy, and sonodynamic therapy have made great progress in cancer therapy, the …
radiotherapy, and sonodynamic therapy have made great progress in cancer therapy, the …
Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting
The clinical use of tumour-infiltrating lymphocytes for the treatment of solid tumours is
hindered by the need to obtain large and fresh tumour fractions, which is often not feasible in …
hindered by the need to obtain large and fresh tumour fractions, which is often not feasible in …
Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting
Adoptive cell therapies require the recovery and expansion of highly potent tumour-
infiltrating lymphocytes (TILs). However, TILs in tumours are rare and difficult to isolate …
infiltrating lymphocytes (TILs). However, TILs in tumours are rare and difficult to isolate …
Nanoparticle amplification labeling for high-performance magnetic cell sorting
Magnetic cell sorting is an enabling tool for the isolation of specific cellular subpopulations
for downstream applications and requires the cells to be labeled by a sufficient number of …
for downstream applications and requires the cells to be labeled by a sufficient number of …
Bioorthogonal microbubbles with antifouling nanofilm for instant and suspended enrichment of circulating tumor cells
Y Xiang, H Zhang, H Lu, B Wei, C Su, X Qin, M Fang… - ACS …, 2023 - ACS Publications
Integrating clinical rare cell enrichment, culture, and single-cell phenotypic profiling is
currently hampered by the lack of competent technologies, which typically suffer from weak …
currently hampered by the lack of competent technologies, which typically suffer from weak …
[HTML][HTML] Integrated microfluidic single-cell immunoblotting chip enables high-throughput isolation, enrichment and direct protein analysis of circulating tumor cells
A Abdulla, T Zhang, S Li, W Guo, AR Warden… - Microsystems & …, 2022 - nature.com
Effective capture and analysis of a single circulating tumor cell (CTC) is instrumental for
early diagnosis and personalized therapy of tumors. However, due to their extremely low …
early diagnosis and personalized therapy of tumors. However, due to their extremely low …
Poly (ethylene oxide) concentration gradient-based microfluidic isolation of circulating tumor cells
Y Cheng, S Zhang, L Qin, J Zhao, H Song… - Analytical …, 2023 - ACS Publications
Circulating tumor cells (CTCs) have emerged as promising circulating biomarkers for non-
invasive cancer diagnosis and management. Isolation and detection of CTCs in clinical …
invasive cancer diagnosis and management. Isolation and detection of CTCs in clinical …