[HTML][HTML] Minocycline mitigates Aβ and TAU pathology, neuronal dysfunction, and death in the PSEN1 E280A cholinergic-like neurons model of familial Alzheimer's …
D Giraldo-Berrio, M Jimenez-Del-Rio… - Neuropharmacology, 2024 - Elsevier
Familial Alzheimer's disease (FAD) presenilin 1 E280A (PSEN1 E280A) is a severe
neurological condition due to the loss of cholinergic neurons (ChNs), accumulation of …
neurological condition due to the loss of cholinergic neurons (ChNs), accumulation of …
Pyroptosis Signature Gene CHMP4B Regulates Microglia Pyroptosis by Inhibiting GSDMD in Alzheimer's Disease
Y Ding, SY Li, W Lv, L Li, HW Zhang, Z Zhang… - Molecular …, 2024 - Springer
In this study, we aimed to work through the key genes involved in the process of pyroptosis
in Alzheimer's disease (AD) to identify potential biomarkers using bioinformatics technology …
in Alzheimer's disease (AD) to identify potential biomarkers using bioinformatics technology …
[HTML][HTML] The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions
C Villaorduña, L Barrios-Arpi, B Lira-Mejía… - Toxics, 2024 - mdpi.com
This study aimed to investigate the toxicity of the fungicide ipconazole on oxidative status,
cell death and inflammasome complex activation in the hypothalamus, cerebral cortex …
cell death and inflammasome complex activation in the hypothalamus, cerebral cortex …
GSDMD knockout alleviates sepsis-associated skeletal muscle atrophy by inhibiting IL18/AMPK signaling
Y Zhang, T Li, Y Liu, C Wang, D Wang, L Xu, H Zhao… - Shock, 2023 - journals.lww.com
Background Sepsis commonly leads to skeletal muscle atrophy, characterized by substantial
muscle weakness and degeneration, ultimately contributing to an adverse prognosis …
muscle weakness and degeneration, ultimately contributing to an adverse prognosis …
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
A Haapasalo, N Huber, T Hietanen, S Heikkinen… - bioRxiv, 2024 - biorxiv.org
Frontotemporal dementia (FTD) is the second most common cause of dementia in patients
under 65 years, characterized by diverse clinical symptoms, neuropathologies, and genetic …
under 65 years, characterized by diverse clinical symptoms, neuropathologies, and genetic …
[PDF][PDF] Mechanisms of neurodegeneration in frontotemporal dementia: focus on synaptic dysfunction
N Huber - 2024 - erepo.uef.fi
During life, neurodegenerative diseases along with loss of neurons and their proper function
as well as deposition and accumulation of pathological proteins might eventually emerge …
as well as deposition and accumulation of pathological proteins might eventually emerge …