Drug resistance and treatment failure in leishmaniasis: A 21st century challenge

A Ponte-Sucre, F Gamarro, JC Dujardin… - PLoS neglected …, 2017 - journals.plos.org
Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently
needed on a global basis because treatment failure is an increasing problem. Drug …

Laboratory diagnostics for human Leishmania infections: a polymerase chain reaction-focussed review of detection and identification methods

I Gow, NC Smith, D Stark, J Ellis - Parasites & Vectors, 2022 - Springer
Leishmania infections span a range of clinical syndromes and impact humans from many
geographic foci, but primarily the world's poorest regions. Transmitted by the bite of a female …

Eliminating visceral leishmaniasis in South Asia: the road ahead

S Rijal, S Sundar, D Mondal, P Das, J Alvar, M Boelaert - bmj, 2019 - bmj.com
Eliminating visceral leishmaniasis in South Asia: the road ahead Page 1 the bmj | BMJ 2019;364:k5224
| doi: 10.1136/bmj.k5224 1 NEGLECTED DISEASES AND INNOVATION IN SOUTH ASIA …

Elimination of visceral leishmaniasis on the Indian subcontinent

OP Singh, E Hasker, M Boelaert… - The Lancet infectious …, 2016 - thelancet.com
Visceral leishmaniasis is a serious public health problem on the Indian subcontinent,
causing high morbidity and mortality. The governments in the region launched a visceral …

A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+ MPL-SE vaccine for use in the prevention of visceral leishmaniasis

J Chakravarty, S Kumar, S Trivedi, VK Rai, A Singh… - Vaccine, 2011 - Elsevier
Healthy Indian adult volunteers, with or without a history of leishmaniasis, were evaluated for
evidence of previous infection with Leishmania donovani based on the direct agglutination …

Health-seeking behaviour, diagnostics and transmission dynamics in the control of visceral leishmaniasis in the Indian subcontinent

GF Medley, TD Hollingsworth, PL Olliaro, ER Adams - Nature, 2015 - nature.com
Countries in the Indian subcontinent have committed to reducing the incidence of kala-azar,
a clinical manifestation of visceral leishmaniasis, to below 1 in 10,000 by 2020. We address …

Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis

MR Perry, S Wyllie, A Raab… - Proceedings of the …, 2013 - National Acad Sciences
The Indian subcontinent is the only region where arsenic contamination of drinking water
coexists with widespread resistance to antimonial drugs that are used to treat the parasitic …

Understanding the economic impact of leishmaniasis on households in endemic countries: a systematic review

T Sunyoto, M Boelaert, F Meheus - Expert review of anti-infective …, 2019 - Taylor & Francis
Introduction: Leishmaniasis is a poverty-related disease that causes a significant
socioeconomic burden to affected households. Visceral leishmaniasis is fatal if untreated …

Socioeconomic benefit to individuals of achieving 2020 targets for four neglected tropical diseases controlled/eliminated by innovative and intensified disease …

EJ Lenk, WK Redekop, M Luyendijk… - PLoS neglected …, 2018 - journals.plos.org
Background The control or elimination of neglected tropical diseases (NTDs) has targets
defined by the WHO for 2020, reinforced by the 2012 London Declaration. We estimated the …

Arsenic exposure and outcomes of antimonial treatment in visceral leishmaniasis patients in Bihar, India: a retrospective cohort study

MR Perry, VK Prajapati, J Menten, A Raab… - PLoS neglected …, 2015 - journals.plos.org
Background In the late twentieth century, emergence of high rates of treatment failure with
antimonial compounds (SSG) for visceral leishmaniasis (VL) caused a public health crisis in …