Macrophage polarization and its role in liver disease

C Wang, C Ma, L Gong, Y Guo, K Fu, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

Macrophages: versatile players in renal inflammation and fibrosis

PMK Tang, DJ Nikolic-Paterson, HY Lan - Nature Reviews Nephrology, 2019 - nature.com
Macrophages have important roles in immune surveillance and in the maintenance of
kidney homeostasis; their response to renal injury varies enormously depending on the …

[HTML][HTML] The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy

Q Yang, N Guo, Y Zhou, J Chen, Q Wei… - Acta Pharmaceutica Sinica …, 2020 - Elsevier
Macrophages have a leading position in the tumor microenvironment (TME) which paves the
way to carcinogenesis. Initially, monocytes and macrophages are recruited to the sites …

Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways

M Qian, S Wang, X Guo, J Wang, Z Zhang, W Qiu… - Oncogene, 2020 - nature.com
Exosomes are emerging as important elements that participate in intercellular
communication and tumor microenvironment modulation, but the exact mechanisms by …

Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

J Xu, J Zhang, Z Zhang, Z Gao, Y Qi, W Qiu, Z Pan… - Cell Death & …, 2021 - nature.com
Exosomes participate in intercellular communication and glioma microenvironment
modulation, but the exact mechanisms by which glioma-derived exosomes (GDEs) promote …

Engineering cells for precision drug delivery: New advances, clinical translation, and emerging strategies

CJ Chao, E Zhang, Z Zhao - Advanced Drug Delivery Reviews, 2023 - Elsevier
Cells have emerged as a promising new form of drug delivery carriers owing to their
distinguished advantages such as naturally bypassing immune recognition, intrinsic …

[HTML][HTML] Glioma stem cells and their roles within the hypoxic tumor microenvironment

NH Boyd, AN Tran, JD Bernstock, T Etminan… - Theranostics, 2021 - ncbi.nlm.nih.gov
Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …

Mechanisms of macrophage plasticity in the tumor environment: manipulating activation state to improve outcomes

TD Ricketts, N Prieto-Dominguez, PS Gowda… - Frontiers in …, 2021 - frontiersin.org
Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …

Regulation of human macrophage M1–M2 polarization balance by hypoxia and the triggering receptor expressed on myeloid cells-1

F Raggi, S Pelassa, D Pierobon, F Penco… - Frontiers in …, 2017 - frontiersin.org
Macrophages (Mf) are a heterogeneous population of tissue-resident professional
phagocytes and a major component of the leukocyte infiltrate at sites of inflammation …

Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways

X Guo, W Qiu, Q Liu, M Qian, S Wang, Z Zhang, X Gao… - Oncogene, 2018 - nature.com
While immunosuppressive environments mediated by myeloid-derived suppressor cells
(MDSCs) have been well documented in glioma patients, the mechanisms of MDSC …