The N-methyl-d-aspartate receptor (NMDAR) antagonist (R, S)-ketamine causes rapid onset
and sustained antidepressant actions in treatment-resistant patients with major depressive …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal
survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating …

There is a long-standing paradox that NMDA (N-methyl-d-aspartate) receptors (NMDARs)
can both promote neuronal health and kill neurons. Recent studies show that NMDAR …

Type 2 diabetes (T2D) is a heterogeneous complex disease affecting more than 29 million
Americans alone with a rising prevalence trending toward steady increases in the coming …

PPARγ coactivator 1α (PGC-1α) is a potent stimulator of mitochondrial biogenesis and
respiration. Since the mitochondrial electron transport chain is the main producer of reactive …

CREB and its close relatives are now widely accepted as prototypical stimulus-inducible
transcription factors. In many cell types, these factors function as effector molecules that …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …

Polyphenols are an important class of phytochemicals, and several lines of evidence have
demonstrated their beneficial effects in the context of a number of pathologies including …

Altered expression and function of the transcription factor cyclic AMP response-binding
protein (CREB) has been identified to play an important role in cancer and is associated with …