The development of alcohol use disorder (AUD) involves binge or heavy drinking to high
levels of intoxication that leads to compulsive intake, the loss of control in limiting intake, and …

Sleep is vital to cognitive performance, productivity, health and well-being. Earlier theories of
sleep presumed that it occurred at the level of the whole organism and that it was governed …

RNA interference (RNAi) has been extensively employed for in vivo research since its use
was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it …

Sleep is homeostatically regulated with sleep pressure accumulating with the increasing
duration of prior wakefulness. Yet, a clear understanding of the molecular components of the …

The historic sleep regulatory paradigm invokes “top-down” imposition of sleep on the brain
by sleep regulatory circuits. While remaining conceptually useful, many sleep phenomena …

This review details tumor necrosis factor alpha (TNF) biology and its role in sleep, and
describes how TNF medications influence sleep/wake activity. Substantial evidence from …

Obesity is associated with increased risk for developing pancreatic cancer, and it is
suggested that insulin resistance provides the missing link. Here we demonstrate that under …

Symptoms commonly associated with sleep loss and chronic inflammation include
sleepiness, fatigue, poor cognition, enhanced sensitivity to pain and kindling stimuli, excess …

Sleep homeostasis means that a prolonged period of wakefulness is followed by a
prolonged period of sleep. Sleep in mammals and birds sleep consists of two main phases …

Sleep intensity is adjusted by the length of previous awake time, and under tight homeostatic
control by protein phosphorylation. Here, we establish microglia as a new cellular …