Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …

Epidermal growth factor receptor (EGFR) is an oncogenic drug target and plays a critical role
in several cellular functions including cancer cell growth, survival, proliferation …

Spontaneous dimerization of EGF receptors (EGFR) and dysregulation of EGFR signaling
has been associated with the development of different cancers. Under normal physiological …

Neurotensin receptor-3 or sortilin is a vacuolar protein sorting 10 protein domain (Vps10p)
has been firstly discovered in the human brain, it acts as receptor or co-receptor of the cell …

There is an unmet clinical need to develop novel strategies to overcome resistance to
tyrosine kinase inhibitors (TKI) in patients with oncogene-driven lung adenocarcinoma …

The relevance of this topic due to the need for further theoretical development and practical
implementation of the methods of mediation and restorative approach as the most important …

Sortilin, also known as neurotensin receptor-3, is a member of the Vps10p domain receptors
family, and it was first discovered in the human brain. It mainly acts as a receptor or a co …

Lung cancer is the leading cause of cancer death around the world. Patients that have been
diagnosed with lung cancer have poor prognosis and a low survival rate. Conventional …

Most cancers are" addicted" to a supply of fatty acids (FAs) and exhibit brisk de novo FA
synthesis. Upregulation of the lipogenic enzyme fatty acid synthase (FASN) is a near …