The glomerular basement membrane (GBM) is a key component of the glomerular capillary
wall and is essential for kidney filtration. The major components of the GBM include …

The ability of animal cells to sense, adhere to and remodel their local extracellular matrix
(ECM) is central to control of cell shape, mechanical responsiveness, motility and signalling …

Extracellular matrix (ECM) is the foundation on which all cells and organs converge to
orchestrate normal physiological functions. In the setting of pathology, the ECM is modified …

Vascular basement membrane (BM) thickening has been hailed over half a century as the
most prominent histological lesion in diabetic microangiopathy, and represents an early …

Background Accumulation of extracellular matrix in organs and tissues is a feature of both
aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis …

Current protocols for producing cerebellar neurons from human pluripotent stem cells
(hPSCs) often rely on animal co-culture and mostly exist as monolayers, limiting their …

Age‐related macular degeneration (AMD) is a major cause of vision impairment in the
Western World, and with the aging world population, its incidence is increasing. As of today …

Heterogeneity within the glycocalyx influences cell adhesion mechanics and signaling.
However, the role of specific glycosylation subtypes in influencing cell mechanics via …

The basement membrane (BM) is a specialized layer of extracellular matrix components that
plays a central role in maintaining lung and kidney functions. Although the composition of …

Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on
kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of …