The neurodevelopmental model of schizophrenia, which posits that the illness is the end
state of abnormal neurodevelopmental processes that started years before the illness onset …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Available methods for differentiating human embryonic stem cells (ESCs) and induced
pluripotent cells (iPSCs) into neurons are often cumbersome, slow, and variable …

Loss of neurons after brain injury and in neurodegenerative disease is often accompanied
by reactive gliosis and scarring, which are difficult to reverse with existing treatment …

Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in
obtaining live neurons from patients and the inability to model the sporadic form of the …

Direct lineage reprogramming is a promising approach for human disease modeling and
regenerative medicine, with poorly understood mechanisms. Here, we reveal a hierarchical …

The generation of large numbers of functional human hepatocytes for cell-based
approaches to liver disease is an important and unmet goal. Direct reprogramming of …

Human cell reprogramming technologies offer access to live human neurons from patients
and provide a new alternative for modeling neurological disorders in vitro. Neural electrical …

The induction of pluripotency or trans-differentiation of one cell type to another can be
accomplished with cell-lineage-specific transcription factors. Here, we report that repression …

Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …