Polo-like kinase 1 inhibitors in human cancer therapy: development and therapeutic potential
Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …
[HTML][HTML] Present and future perspective on PLK1 inhibition in cancer treatment
M Chiappa, S Petrella, G Damia, M Broggini… - Frontiers in …, 2022 - frontiersin.org
Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …
[HTML][HTML] Plk1 overexpression induces chromosomal instability and suppresses tumor development
G de Cárcer, SV Venkateswaran, L Salgueiro… - Nature …, 2018 - nature.com
Abstract Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors,
being frequently considered as an oncogene and an attractive cancer target. However, its …
being frequently considered as an oncogene and an attractive cancer target. However, its …
A comprehensive review of genetic alterations and molecular targeted therapies for the implementation of personalized medicine in acute myeloid leukemia
Acute myeloid leukemia (AML) is an extremely heterogeneous disease defined by the clonal
growth of myeloblasts/promyelocytes not only in the bone marrow but also in peripheral …
growth of myeloblasts/promyelocytes not only in the bone marrow but also in peripheral …
[HTML][HTML] A mechanism for controlled breakage of under-replicated chromosomes during mitosis
While DNA replication and mitosis occur in a sequential manner, precisely how cells
maintain their temporal separation and order remains elusive. Here, we unveil a double …
maintain their temporal separation and order remains elusive. Here, we unveil a double …
Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution
Current microtubule-targeting agents (MTAs) remain amongst the most important antimitotic
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …
Pharmacoinformatics approach for the identification of Polo-like kinase-1 inhibitors from natural sources as anti-cancer agents
Abstract Polo-like kinase-1 (PLK-1) plays a key role in cell cycle progression during mitosis.
Overexpression/dysfunction of PLK-1 is directly associated with cancerous transformation …
Overexpression/dysfunction of PLK-1 is directly associated with cancerous transformation …
Polo-like Kinase 1 as an emerging drug target: structure, function and therapeutic implications
Abstract Polo-like kinase 1 (PLK1) is a conserved mitotic serine-threonine protein kinase,
functions as a regulatory protein, and is involved in the progression of the mitotic cycle. It …
functions as a regulatory protein, and is involved in the progression of the mitotic cycle. It …
[HTML][HTML] Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth
Lung cancer is a major contributor to cancer-related death worldwide. siRNA
nanomedicines are powerful tools for cancer therapeutics. However, there are challenges to …
nanomedicines are powerful tools for cancer therapeutics. However, there are challenges to …
[HTML][HTML] Evolving therapeutic strategies to exploit chromosome instability in cancer
LL Thompson, LMP Jeusset, CC Lepage, KJ McManus - Cancers, 2017 - mdpi.com
Cancer is a devastating disease that claims over 8 million lives each year. Understanding
the molecular etiology of the disease is critical to identify and develop new therapeutic …
the molecular etiology of the disease is critical to identify and develop new therapeutic …