Decades of advancements in immuno-oncology have enabled the development of current
immunotherapies, which provide long-term treatment responses in certain metastatic cancer …

Regulatory T-cells (TREG) are diverse populations of lymphocytes that regulate the adaptive
immune response in higher vertebrates. TREG delete autoreactive T-cells, induce tolerance …

Objective Inadequate immunoregulation and elevated inflammation may be risk factors for
posttraumatic stress disorder (PTSD), and microbial inputs are important determinants of …

The nervous system and the immune system (IS) are two integrative systems that work
together to detect threats and provide host defense, and to maintain/restore homeostasis …

The prevalence of inflammatory diseases is increasing in modern urban societies.
Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or …

Context Inflammation is increasingly recognized as contributing to the pathogenesis of major
depressive disorder (MDD), even in individuals who are otherwise medically healthy. Most …

There are several hypotheses concerning the underlying pathophysiological mechanisms of
major depression, which centre largely around adaptive changes in neuronal transmission …

Leptospirosis, a re-emerging zoonotic disease, remains a significant global health concern,
especially amid floods and disasters such as the Kakhovka Dam destruction. As is known …

The involvement of central and peripheral inflammation in the pathogenesis and prognosis
of major depressive disorder (MDD) has been demonstrated. The increase of pro …

Sympathoadrenergic pathways are crucial to the communication between the nervous
system and the immune system. The present review addresses emerging issues in the …