MicroRNA-based diagnosis and therapy

PTB Ho, IM Clark, LTT Le - International journal of molecular sciences, 2022 - mdpi.com
MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene
expression. Alteration in miRNA expression results in changes in the profile of genes …

Epigenetics of colorectal cancer: biomarker and therapeutic potential

G Jung, E Hernández-Illán, L Moreira… - Nature reviews …, 2020 - nature.com
Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

MicroRNA as biomarkers and diagnostics

J Wang, J Chen, S Sen - Journal of cellular physiology, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are a group of small non‐coding RNAs that are involved in regulating
a range of developmental and physiological processes; their dysregulation has been …

Epigenetic alterations in colorectal cancer: emerging biomarkers

Y Okugawa, WM Grady, A Goel - Gastroenterology, 2015 - Elsevier
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

Biomarkers in colorectal cancer: current research and future prospects

OO Ogunwobi, F Mahmood, A Akingboye - International journal of …, 2020 - mdpi.com
Colorectal cancer (CRC) is a leading cause of death worldwide, despite progress made in
detection and management through surgery, chemotherapy, radiotherapy, and …

[HTML][HTML] Circulating biomarkers for early detection and clinical management of colorectal cancer

M Marcuello, V Vymetalkova, RPL Neves… - Molecular Aspects of …, 2019 - Elsevier
New non-invasive approaches that can complement and improve on current strategies for
colorectal cancer (CRC) screening and management are urgently needed. A growing …

[HTML][HTML] Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances

G Lech, R Słotwiński, M Słodkowski… - World journal of …, 2016 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the second most commonly diagnosed cancer among females
and third among males worldwide. It also contributes significantly to cancer-related deaths …

Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs

L Min, S Zhu, L Chen, X Liu, R Wei, L Zhao… - Journal of …, 2019 - Taylor & Francis
Early diagnosis of colon cancer (CC) is clinically important, as it can significantly improve
patients' survival rate and quality of life. Although the potential role for small extracellular …

Circulating exosomal microRNAs as biomarkers of colon cancer

H Ogata-Kawata, M Izumiya, D Kurioka, Y Honma… - PloS one, 2014 - journals.plos.org
Purpose Exosomal microRNAs (miRNAs) have been attracting major interest as potential
diagnostic biomarkers of cancer. The aim of this study was to characterize the miRNA …

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

MV Iorio, CM Croce - EMBO molecular medicine, 2012 - embopress.org
Early studies have shown how aberrantly expressed microRNAs are a hallmark of several
diseases like cancer. MicroRNA expression profiling was shown to be associated with …