Most viruses are naturally immunogenic and can be engineered to express tumor antigen
transgenes. Moreover, many types of recombinant viruses have been shown to infect …

Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide in human
beings. Surgery, chemotherapy, radiotherapy and targeted therapies are the conventional …

CD8+ CTL play important roles against malignancy in both active and passive
immunotherapy. Nonetheless, the success of antitumor CTL responses may be improved by …

Recombinant poxviruses (vaccinia and fowlpox) expressing tumor-associated antigens are
currently being evaluated in clinical trials as cancer vaccines to induce tumor-specific …

Prostvac is a prostate cancer vaccine regimen consisting of a recombinant vaccinia vector
as a primary vaccination, followed by multiple booster vaccinations employing a …

PURPOSE: Docetaxel has activity against androgen-independent prostate cancer and
preclinical studies have shown that taxane-based chemotherapy can enhance antitumor …

The activation of a T cell has been shown to require two signals via molecules present on
professional antigen-presenting cells: signal 1, via a peptide/MHC complex; and signal 2 …

Purpose: Taxanes comprise some of the most widely used cancer chemotherapeutic agents.
Members of this drug family, including docetaxel, are commonly used to treat breast …

Abstract HER-2/neu (neu-N) transgenic mice, which express the nontransforming rat proto-
oncogene, develop spontaneous focal mammary adenocarcinomas beginning at 5–6 …

Treating cancer with vaccines has been a challenging field of investigation since the 1950s.
Over the years, the lack of effective active immunotherapies has led to the development of …