The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription
factors, found throughout all three kingdoms of life; bHLH/PAS members “sense” …

SUMMARY PAS domains are newly recognized signaling domains that are widely
distributed in proteins from members of the Archaea and Bacteria and from fungi, plants …

Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2
tension and is necessary for transcriptional activation mediated by the erythropoietin gene …

In this era of jet travel, our body'remembers' the previous time zone, such that when we
travel, our sleep–wake pattern, mental alertness, eating habits and many other physiological …

Eclosion, or emergence of adult flies from the pupa, and locomotor activity of adults occur
rhythmically in Drosophila melanogaster, with a circadian period of about 24 hours. Here, a …

Over the past decade, PAS domains have been identified in dozens of signal transduction
molecules and various forms have been found in animals, plants, and prokaryotes. In this …

Previous studies suggested that Roundabout (Robo) is a repulsive guidance receptor on
growth cones that binds to an unknown midline ligand. Here we present genetic evidence …

The aryl hydrocarbon (Ah) receptor binds various environmental pollutants, such as
polycyclic aromatic hydrocarbons, heterocyclic amines, and polychlorinated aromatic …

▪ Abstract The aryl hydrocarbon (Ah) receptor has occupied the attention of toxicologists for
over two decades. Interest arose from the early observation that this soluble protein played …

Background Cell-fate specification and tissue differentiation during development are largely
achieved by the regulation of gene transcription. Results As a first step to creating a …