Highlights•Alternative materials and actuation methods for mLSI are discussed.•Novel mLSI
components and architectures are reviewed.•Recent attempts to automate the design and …

As one of the most promising lab-on-a-chip systems, flow-based microfluidic biochips are
being increasingly used for automatically executing various laboratory procedures in biology …

Microfluidic systems have been investigated as practical tools in the fields of biomedical
engineering, analytical chemistry, materials science, and biological research. Yet the …

Continuous-flow microfluidic biochips (CFMBs), also known as lab-on-a-chip platforms, have
attracted considerable attentions in the past two decades and have been widely used in …

Continuous-flow microfluidic large-scale integration (mLSI) shows increasing importance in
biological/chemical fields, thanks to its advantages in miniaturization and high throughput …

System-architecture design optimization of flow-based microfluidic biochips has been
extensively investigated over the past decade. Most of the prior work, however, is still based …

Continuous-flow microfluidics rapidly evolved in the last decades as a solution to automate
laboratory procedures in molecular biology and biochemistry. Therefore, the physical design …

Digital microfluidic biochips (DMFBs) are being increasingly used for DNA sequencing, point-
of-care clinical diagnostics, and immunoassays. DMFBs based on a micro-electrode-dot …

Recent advances in flow-based microfluidic biochips have enabled the emergence of lab-on-
a-chip devices for bimolecular recognition and point-of-care disease diagnostics. However …

Continuous-flow microfluidics have evolved rapidly in the last decades, due to their
advantages in effective and accurate control. However, complex control results in …