The first obligatory phase of mammalian infection by Plasmodium parasites, the causative
agents of malaria, occurs in the liver of the host. This stage of Plasmodium infection bears …

The concept of repurposing previously approved medications to the treatment of new
indications by taking advantage of off-target effects has gained traction in recent years …

Malaria remains one of the world's most prevalent tropical diseases because of its high
mortality and morbidity burden, as well as its economic and social impacts on the …

Background Highly charged compounds typically suffer from low membrane permeability
and thus are generally regarded as sub-optimal drug candidates. Nonetheless, the highly …

Infectious diseases caused by pathogenic protozoa are among the most significant causes
of death in humans. Therapeutic options are scarce and massively challenged by the …

Cytoskeletal structures of Apicomplexan parasites are important for parasite replication,
motility, invasion to the host cell and survival. Apicortin, an Apicomplexan specific protein …

Despite a remarkable improvement in health care and continued drug discovery efforts,
malaria control efforts are continuously challenged by the emergence of drug-resistant …

Mammalian transport proteins are essential components of cellular function that have been
very successfully exploited as drug targets. Over the past few years, a small but increasing …

Infection of liver cells by Plasmodium, the malaria parasite, is a clinically silent, obligatory
step of the parasite's life cycle. The authors studied the progression of Plasmodium infection …

In a follow‐up study to our reports of N‐cinnamoylated chloroquine and quinacrine
analogues as promising dual‐stage antimalarial leads with high in vitro potency against …