The genetics of transcription factor DNA binding variation
Most complex trait-associated variants are located in non-coding regulatory regions of the
genome, where they have been shown to disrupt transcription factor (TF)-DNA binding …
genome, where they have been shown to disrupt transcription factor (TF)-DNA binding …
Lipoprotein lipase: from gene to obesity
H Wang, RH Eckel - American Journal of Physiology …, 2009 - journals.physiology.org
Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues, including
adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate …
adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate …
Transcriptional regulatory elements in the human genome
GA Maston, SK Evans, MR Green - Annu. Rev. Genomics Hum …, 2006 - annualreviews.org
The faithful execution of biological processes requires a precise and carefully orchestrated
set of steps that depend on the proper spatial and temporal expression of genes. Here we …
set of steps that depend on the proper spatial and temporal expression of genes. Here we …
Lipoprotein lipase: structure, function, regulation, and role in disease
Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of
circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified …
circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified …
Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease: a meta-analysis
HH Wittrup, A Tybjærg-Hansen, BG Nordestgaard - Circulation, 1999 - Am Heart Assoc
Background—We assessed in meta-analyses the effect of the Gly188Glu, Asp9Asn,
Asn291Ser, and Ser447Ter substitutions in lipoprotein lipase in the heterozygous state on …
Asn291Ser, and Ser447Ter substitutions in lipoprotein lipase in the heterozygous state on …
Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
C Holm, T Østerlund, H Laurell… - Annual review of …, 2000 - annualreviews.org
Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is a major
determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays a …
determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays a …
Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase
Allelic variation in 9.7 kb of genomic DNA sequence from the human lipoprotein lipase gene
(LPL) was scored in 71 healthy individuals (142 chromosomes) from three populations …
(LPL) was scored in 71 healthy individuals (142 chromosomes) from three populations …
[PDF][PDF] Lipoprotein lipase: physiology, biochemistry, and molecular biology
IJ Goldberg, M Merkel - Front Biosci, 2001 - article.imrpress.com
[Frontiers in Bioscience 6, d388-405, March 1, 2001] 388 LIPOPROTEIN LIPASE:
PHYSIOLOGY, BIOCHEMISTRY, AND MOLECULAR BIOLOGY Ira Page 1 [Frontiers in …
PHYSIOLOGY, BIOCHEMISTRY, AND MOLECULAR BIOLOGY Ira Page 1 [Frontiers in …
Molecular pathobiology of the human lipoprotein lipase gene
V Murthy, P Julien, C Gagné - Pharmacology & therapeutics, 1996 - Elsevier
Lipoprotein lipase (LPL; EC 3.1. 1.34) is a key enzyme in the metabolism of lipids. Many
diseases, including obesity, coronary heart disease, chylomicronemia (pancreatitis), and …
diseases, including obesity, coronary heart disease, chylomicronemia (pancreatitis), and …
The familial chylomicronemia syndrome
S Santamarina-Fojo - Endocrinology and metabolism clinics of North …, 1998 - Elsevier
The chylomicronemia syndrome is a disorder characterized by severe fasting
hypertriglyceridemia and massive accumulations of chylomicrons in plasma that can lead to …
hypertriglyceridemia and massive accumulations of chylomicrons in plasma that can lead to …