The antiretroviral protease inhibitor atazanavir inhibits hepatic uridine diphosphate
glucuronosyltransferase (UGT) 1A1, thereby preventing the glucuronidation and elimination …

摘要胆红素作为人体的一种重要内源性物质# 是临床诊断黄疸的主要依据#
也是肝功能的重要指标& 本文在简述胆红素代谢过程'代谢动力学及代谢异常的基础上# …

Background Drug-related toxicity has been one of the main causes of antiretroviral treatment
discontinuation. However, its determinants are not fully understood. Aim of this study was to …

The adherence profile of HIV-infected patients predicts the therapeutic outcome, in particular
during the early phase of antiretroviral therapy (ART). We conducted a prospective …

Bilirubin, an important endogenous substances and liver function index in humans, is
primarily eliminated via UGT1A1-catalyzed glucuronidation. Instability of bilirubin and its …

Background. Some patients are not prescribed atazanavir because of concern about
possible jaundice. Atazanavir-associated hyperbilirubinemia correlates with UGT1A1 …

Objectives It is uncertain whether HIV-1 antiretroviral exposure and clinical response varies
between males and females or different race/ethnic groups. We describe ritonavir-enhanced …

Bilirubin-related adverse reactions (ADR, eg, jaundice and hyperbilirubinemia) induced by
herbs rich in certain polyphenolic acids are widely reported. However, the causes and the …

Objective: Bilirubin is an antioxidant that may suppress lipid oxidation. Elevated bilirubin is
associated with decreased cardiovascular events in HIV-uninfected populations. We …

Background Malawi's national antiretroviral therapy program provides atazanavir/ritonavir–
based second line regimens which cause concentration-dependent rise in indirect bilirubin …