[HTML][HTML] Contemporary techniques and potential transungual drug delivery nanosystems for the treatment of onychomycosis

WH Abd-Elsalam, SM Abouelatta - AAPS PharmSciTech, 2023 - Springer
The humanoid nail is considered an exceptional protective barrier that is formed mainly from
keratin. Onychomycosis is the cause of 50% of nail infections that is generally caused by …

[HTML][HTML] Itraconazole and difluorinated-curcumin containing chitosan nanoparticle loaded hydrogel for amelioration of onychomycosis

P Kesharwani, M Fatima, V Singh, A Sheikh… - Biomimetics, 2022 - mdpi.com
Onychomycosis is a nail infection caused by a fungus, Trichophyton mentagrophytes, that is
responsible for major nail infections. The best method suited for treating such infections …

[HTML][HTML] Antifungal nail lacquer for enhanced transungual delivery of econazole nitrate

V Puri, R Savla, K Chen, K Robinson, A Virani… - Pharmaceutics, 2022 - mdpi.com
The fungal disease of the nail, onychomycosis, which is also the most prevalent nail
disturbance, demands effective topical treatment options considering the possible adverse …

Design and evaluation of microemulsion-based efinaconazole formulations for targeted treatment of onychomycosis through transungual route: Ex vivo and nail …

V Agrawal, R Patel, M Patel, K Thanki… - Colloids and Surfaces B …, 2021 - Elsevier
The onychomycosis treatment remains a big challenge for onychologist due to the shorter
nail residence time of topical formulations and the lack of availability of novel formulations in …

[HTML][HTML] Constant Voltage Iontophoresis Technique to Deliver Terbinafine via Transungual Delivery System: Formulation Optimization Using Box–Behnken Design …

AB Nair, BE Al-Dhubiab, J Shah, B Gorain, S Jacob… - Pharmaceutics, 2021 - mdpi.com
Topical therapy of antifungals is primarily restricted due to the low innate transport of drugs
through the thick multi-layered keratinized nail plate. The objective of this investigation was …

Design, characterization, and evaluation of efinaconazole loaded poly (D, L-lactide-co-glycolide) nanocapsules for targeted treatment of onychomycosis

V Agrawal, R Patel, M Patel - Journal of Drug Delivery Science and …, 2023 - Elsevier
Polymeric nanocapsules have recently gained increased interest as antifungal delivery
carriers owing to a microstructure composed of a liquid/solid core containing a drug that is …

[HTML][HTML] Assessment of the nail penetration of antifungal agents, with different physico-chemical properties

H Davies-Strickleton, J Cook, S Hannam, R Bennett… - Plos one, 2020 - journals.plos.org
Onychomycosis, or fungal nail infection, is a common fungal infection largely caused by
dermatophyte fungi, such as Trichophyton rubrum or Trichophyton mentagrophytes, which …

[HTML][HTML] Preparation of topical itraconazole with enhanced skin/nail permeability and in vivo antifungal efficacy against superficial mycosis

L Subedi, SY Song, SK Jha, SH Lee, R Pangeni… - Pharmaceutics, 2021 - mdpi.com
In this study, a stable and highly skin-permeable topical delivery system for itraconazole
(ITZ) was designed to provide effective treatment against superficial mycosis. Herein, ITZ …

Gallic acid loaded self-nano emulsifying hydrogel-based drug delivery system against onychomycosis

MS Khan, M Fatima, S Wahab, M Khalid… - …, 2024 - Taylor & Francis
Aim: To developed and investigate gallic acid (GA) loaded self-nanoemulsifying drug
delivery systems (SNEDDS) for treating onychomycosis via transungual route. Materials & …

In-vitro and In-vivo characterization of anti-onychomycotic transungual patches-A systematic review

L Thampi, EJ Gini - Research Journal of Pharmacy and …, 2023 - indianjournals.com
Transungual drug delivery systems distribute therapeutic agents through the human nail, a
unique way for delivering medications for nail disorders caused by fungal infections. The …