An overview of NO signaling pathways in aging

AM Pourbagher-Shahri, T Farkhondeh, M Talebi… - Molecules, 2021 - mdpi.com
Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular
mechanisms and pathways under normal and pathological conditions. NO production, its …

Red blood cell dysfunction: a new player in cardiovascular disease

J Pernow, A Mahdi, J Yang, Z Zhou - Cardiovascular research, 2019 - academic.oup.com
The primary role of red blood cells (RBCs) is to transport oxygen to the tissues and carbon
dioxide to the lungs. However, emerging evidence suggests an important role of the RBC …

CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice

CH Wang, M Lundh, A Fu, R Kriszt, TL Huang… - Science translational …, 2020 - science.org
Brown and brown-like beige/brite adipocytes dissipate energy and have been proposed as
therapeutic targets to combat metabolic disorders. However, the therapeutic effects of cell …

[HTML][HTML] Endothelial nitric oxide synthase in red blood cells: key to a new erythrocrine function?

MM Cortese-Krott, M Kelm - Redox biology, 2014 - Elsevier
Red blood cells (RBC) have been considered almost exclusively as a transporter of
metabolic gases and nutrients for the tissues. It is an accepted dogma that RBCs take up …

Mechanisms and pathophysiological significance of eryptosis, the suicidal erythrocyte death

E Lang, F Lang - Seminars in cell & developmental biology, 2015 - Elsevier
Eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and cell membrane
scrambling, is stimulated by Ca 2+ entry through Ca 2+-permeable, PGE 2-activated cation …

Triggers, inhibitors, mechanisms, and significance of eryptosis: the suicidal erythrocyte death

E Lang, F Lang - BioMed research international, 2015 - Wiley Online Library
Suicidal erythrocyte death or eryptosis is characterized by erythrocyte shrinkage, cell
membrane blebbing, and cell membrane scrambling with phosphatidylserine translocation …

Oxidative stress and suicidal erythrocyte death

F Lang, M Abed, E Lang, M Föller - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Eryptosis, the suicidal erythrocyte death, is characterized by cell shrinkage,
membrane blebbing, and phosphatidylserine translocation to the outer membrane leaflet …

[HTML][HTML] Novel perspectives on redox signaling in red blood cells and platelets in cardiovascular disease

A Mahdi, MM Cortese-Krott, M Kelm, N Li… - Free Radical Biology and …, 2021 - Elsevier
The fundamental physiology of circulating red blood cells (RBCs) and platelets involving
regulation of oxygen transport and hemostasis, respectively, are well-described in the …

[HTML][HTML] Low levels of nitric oxide promotes heme maturation into several hemeproteins and is also therapeutic

A Ghosh, MP Sumi, B Tupta, T Okamoto, K Aulak… - Redox Biology, 2022 - Elsevier
Nitric oxide (NO) is a signal molecule and plays a critical role in the regulation of vascular
tone, displays anti-platelet and anti-inflammatory properties. While our earlier and current …

[HTML][HTML] On the chemical biology of the nitrite/sulfide interaction

MM Cortese-Krott, BO Fernandez, M Kelm, AR Butler… - Nitric Oxide, 2015 - Elsevier
Abstract Sulfide (H 2 S/HS−) has been demonstrated to exert an astounding breadth of
biological effects, some of which resemble those of nitric oxide (NO). While the chemistry …