Because of their function of catalyzing the rearrangement of the carbon chains, thiolases
have attracted increasing attentions over the past decades. The 3-ketoacyl-CoA thiolase …

Highlights•Bioproduced hydroxy acids (HAs) and diols are sustainable plastics
precursors.•Novel pathway design allows for the bioproduction of new-to-nature HAs and …

In vitro biosynthetic pathways that condense and reduce molecules through coenzyme A
(CoASH) activation demand energy and redox power in the form of ATP and NAD (P) H …

Metabolic engineering efforts require enzymes that are both highly active and specific
toward the synthesis of a desired output product to be commercially feasible. The 3 …

The prediction of enzyme activity is one of the main challenges in catalysis. With computer-
aided methods, it is possible to simulate the reaction mechanism at the atomic level …

The biosynthesis of various useful chemicals from simple substrates using industrial
microorganisms is becoming increasingly crucial to address the challenge of dwindling non …

The in vitro synthesis of Coenzyme A (CoA)‐thioester intermediates opens new avenues to
transform simple molecules into more complex and multifunctional ones by assembling cell …

While biomedical investigation has greatly advanced, investigators have lost touch with and
inadvertently corrupted significant nomenclature at the foundation of their science …

Economical and environmentally-friendly routes to convert feedstock chemicals like acetate
into valuable chiral products such as (R)-3-hydroxybutyrate are in demand. Here, seven …

The carbon and energy intensity associated with plastics production from petroleum,
combined with the accumulation of plastics waste in the environment, necessitates the …