Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

High levels of cholesterol are generally considered to be associated with atherosclerosis. In
the past two decades, however, a number of studies have shown that excess cholesterol …

Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Lipid accumulation in podocytes is a major determinant of diabetic kidney disease (DKD)
and identification of potential therapeutic targets by mediating podocyte lipid metabolism …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with
prevalence increasing at an alarming rate worldwide and today, there are no known cures …

Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …

Abstract Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are anti-hyperglycemic agents
that prevent glucose reabsorption in proximal tubular cells. SGLT2i improves renal …

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in
the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple …