Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that takes part in
many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been …

Apigenin is a naturally occurring dietary flavonoid found abundantly in fruits and vegetables.
It possesses a wide range of biological properties that exert antioxidant, anti-inflammatory …

BACKGROUND: Here, we assessed the role of cellular senescence and the senescence
associated secretory phenotype (SASP) in age-related aortic stiffening and endothelial …

Cellular senescence and the senescence‐associated secretory phenotype (SASP)
contribute to age‐related arterial dysfunction, in part, by promoting oxidative stress and …

Coronary microvascular disease (CMD), which affects the arterioles and capillary
endothelium that regulate myocardial perfusion, is an increasingly recognized source of …

Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key
antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is …

Apigenin is a natural flavonoid which is widely found in vegetables and fruits. However, the
mechanism of apigenin in oxidative stress-induced myocardial injury has not been fully …

Context Vascular aging, including endothelial dysfunction secondary to oxidative stress and
inflammation, increases the risk for age-associated cardiovascular disease (CVD). Low …

Brain aging is associated with reduced cognitive function that increases the risk for
dementia. Apigenin is a bioactive plant compound that inhibits cellular aging processes and …

Disrupted biological function, manifesting through the hallmarks of aging, poses one of the
largest threats to healthspan and risk of disease development, such as metabolic disorders …