Autophagy is an intracellular process that facilitates the bulk degradation of cytoplasmic
materials by the vacuole or lysosome in eukaryotes. This conserved process is achieved …

Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining
cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Multi-tyrosine kinase inhibitors (MTKIs) have thus far had limited success in the treatment of
castration-resistant prostate cancer (CRPC). Here, we report a phase I–cleared orally …

Macroautophagy is an evolutionarily conserved dynamic pathway that functions primarily in
a degradative manner. A basal level of macroautophagy occurs constitutively, but this …

Highlights•Autophagy is essential for nutrient recycling and remobilization in plants.•Both
bulk and specific autophagy participate to nutrient recycling.•Autophagy defects result in …

Autophagy is an intracellular protein-degradation process that is conserved across
eukaryotes including yeast and humans. Under nutrient starvation conditions, intracellular …

Highlights•The first wave of potent specific KDM1A inhibitors is currently in Phase I
testing.•The first potent specific KDM5 inhibitor is in preclinical regulatory …

Stroke is a leading cause of mortality and morbidity worldwide. Understanding the
underlying mechanisms is important for developing effective therapies for treating stroke …

The eukaryotic TORC1 kinase assimilates diverse environmental cues, including growth
factors and nutrients, to control growth by tuning anabolic and catabolic processes. In yeast …