Natural killer cell homing and trafficking in tissues and tumors: from biology to application
GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …
against cancer. Although some evidence shows that NK cells can develop in secondary …
[HTML][HTML] Establishment and maintenance of the macrophage niche
M Guilliams, GR Thierry, J Bonnardel, M Bajenoff - Immunity, 2020 - cell.com
Self-maintaining resident macrophages populate all mammalian organs. In addition to their
role as immune sentinels, macrophages perform day-to-day functions essential to tissue …
role as immune sentinels, macrophages perform day-to-day functions essential to tissue …
IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction
In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the
regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as …
regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as …
The role of cytokines in T‐cell memory in health and disease
ME Raeber, Y Zurbuchen, D Impellizzieri… - Immunological …, 2018 - Wiley Online Library
Upon stimulation with their cognate antigen, naive T cells undergo proliferation and
differentiation into effector cells, followed by apoptosis or survival as precursors of long‐lived …
differentiation into effector cells, followed by apoptosis or survival as precursors of long‐lived …
The IL-2 cytokine family in cancer immunotherapy
GC Sim, L Radvanyi - Cytokine & growth factor reviews, 2014 - Elsevier
The use of cytokines from the IL-2 family (also called the common γ chain cytokine family)
such as interleukin (IL)-2, IL-7, IL-15, and IL-21 to activate the immune system of cancer …
such as interleukin (IL)-2, IL-7, IL-15, and IL-21 to activate the immune system of cancer …
Instructive cues of thymic T cell selection
M Irla - Annual Review of Immunology, 2022 - annualreviews.org
A high diversity of αβ T cell receptors (TCRs), capable of recognizing virtually any pathogen
but also self-antigens, is generated during T cell development in the thymus. Nevertheless, a …
but also self-antigens, is generated during T cell development in the thymus. Nevertheless, a …
Transcription factors associated with IL-15 cytokine signaling during NK cell development
X Wang, XY Zhao - Frontiers in immunology, 2021 - frontiersin.org
Natural killer (NK) cells are lymphocytes primarily involved in innate immunity and possess
important functional properties in anti-viral and anti-tumor responses; thus, these cells have …
important functional properties in anti-viral and anti-tumor responses; thus, these cells have …
IL‐15: a central regulator of celiac disease immunopathology
Summary Interleukin‐15 (IL‐15) exerts many biological functions essential for the
maintenance and function of multiple cell types. Although its expression is tightly regulated …
maintenance and function of multiple cell types. Although its expression is tightly regulated …
Differential roles of IL-2 signaling in developing versus mature Tregs
MY Fan, JS Low, N Tanimine, KK Finn… - Cell reports, 2018 - cell.com
Although Foxp3+ regulatory T cells (Tregs) require interleukin-2 (IL-2) for their development,
it has been unclear whether continuing IL-2 signals are needed to maintain lineage stability …
it has been unclear whether continuing IL-2 signals are needed to maintain lineage stability …
Locally sourced: site-specific immune barriers to metastasis
AL Correia - Nature Reviews Immunology, 2023 - nature.com
Tumour cells migrate very early from primary sites to distant sites, and yet metastases often
take years to manifest themselves clinically or never even surface within a patient's lifetime …
take years to manifest themselves clinically or never even surface within a patient's lifetime …