Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

Self-maintaining resident macrophages populate all mammalian organs. In addition to their
role as immune sentinels, macrophages perform day-to-day functions essential to tissue …

In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the
regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as …

Upon stimulation with their cognate antigen, naive T cells undergo proliferation and
differentiation into effector cells, followed by apoptosis or survival as precursors of long‐lived …

The use of cytokines from the IL-2 family (also called the common γ chain cytokine family)
such as interleukin (IL)-2, IL-7, IL-15, and IL-21 to activate the immune system of cancer …

A high diversity of αβ T cell receptors (TCRs), capable of recognizing virtually any pathogen
but also self-antigens, is generated during T cell development in the thymus. Nevertheless, a …

Natural killer (NK) cells are lymphocytes primarily involved in innate immunity and possess
important functional properties in anti-viral and anti-tumor responses; thus, these cells have …

Summary Interleukin‐15 (IL‐15) exerts many biological functions essential for the
maintenance and function of multiple cell types. Although its expression is tightly regulated …

Although Foxp3+ regulatory T cells (Tregs) require interleukin-2 (IL-2) for their development,
it has been unclear whether continuing IL-2 signals are needed to maintain lineage stability …

Tumour cells migrate very early from primary sites to distant sites, and yet metastases often
take years to manifest themselves clinically or never even surface within a patient's lifetime …